Article Analysis: Carbohydrate and Cardiovascular Disease

Carbohydrate and Cardiovascular Disease

Article Analysis: Carbohydrate and Cardiovascular Disease

Instructions:

Locate a peer reviewed or scholarly article that is less than 5 years old on the following topic: Carbohydrate and Cardiovascular Disease Include the following in your review:
1. Title, Author (including credentials), Journal, Date(must be within the last 5 years
2. Explain the article in your own words (who, what, when, and why)
3. Fully discuss the findings
4. What did you learn?
5. Did the article contradict any information in your textbook or previous findings
6. Must submit copy of article

Solution

Article Analysis: Carbohydrate and Cardiovascular Disease

Title: The Association between Carbohydrate-Rich Foods and Risk of Cardiovascular Disease Is Not Modified by Genetic Susceptibility to Dyslipidemia as Determined by 80 Validated Variants

Author Profile:

  1. Emily Sonestedt – MSc in Nutrition from Stockholm University and a Ph.D. in Public Health and Nutritional Epidemiology from Lund University, currently an Associate Professor at Lund University
  2. Sophie Hellstrand – A Research Assistant at Lund University, Holder of an MSc in Nutrition from Stockholm University, and a Ph.D. in Public Health (Diet-Gene Interactions on Dyslipidemia and Cardiovascular Diseases) from Lund University
  3. Christina-Alexandra Schulz- Holds a Diploma Studies Nutrition and Household Studies and now pursuing a Ph.D. Degree in Genetic Epidemiology and Public Health at Lund University
  4. Peter Wallström – A physician in Nutritional Epidemiology at the Department of Clinical Sciences at Lund University in Malmo, Sweden
  5. Isabel Drake – holds a BSc in Medical Science, MSc in Molecular Biology, and a Masters in Public Health, all from Lund University. She is Currently a post-doctoral researcher at Lund University, Clinical Sciences department- Diabetes and Cardiovascular Diseases, Lund University.
  6. Ulrika Ericson – Is currently an associate researcher at Lund University and she holds a BSc in Nutrition from Stockholm University, and a Ph.D. from the Faculty of Medicine specializes in Diabetes and cardiovascular diseases – genetic epidemiology.
  7. Bo Gullberg, Bo Hedblad, Marju Orho-Melander- All have a Degree relating to Nutrition and serve at the Department of Clinical Sciences at Lund University

Journal Date: March 29, 2015

Summary and Findings of the Article

The research article is a cohort study that aims at examining the association between carbohydrates foods intake and the risk of developing an incident ischemic cardiovascular disease(iCVD)- coronary events and an ischemic stroke as well as it depicts if these relationships depend on an individual genetic predisposition to dyslipidemia(Sonestedt et al., 2015). The research was based on examining 26, 445 persons from a Cohort study group, Malmo Diet and Cancer, 2621 experienced ICVD in a 14-year follow. Dietary data was collected as a baseline through a comprehensive diet history design, and the risk factors were measured in 4535 subjects. Specifically, researchers in the study compared 80 genetic deviations associated with individual fat, triglycerides, and HDL-C or LDL-C, to genetic scores and evaluated the interactions between nutritional intakes and the genetic risk scores for iCVD.

Results suggest that subjects who had higher intakes in five groups for whole grains had a 13 percent lower risk for iCVD compared to the lowest group of five. Also, it was found the foods rich in sugar such as sweets and sugary beverages had an association with higher concentrations of triglycerides and lower HDL-C levels. Additionally, there was a positive relationship between high sugar consumption on the risk of iCVD among the low genetic risk score regarding triglycerides(Sonestedt et al., 2015).

Conclusively, the study indicated that persons who consume more carbohydrates had a decreased risk to developing iCVD and there was no evidence of the interactional effect of one’s genetic vulnerabilities for dyslipidemia.

Lesson learned and Conclusions.

This prospective study has equipped me with the knowledge of understanding the interactions between the effect of carbohydrates on the development of ICVD. As such, it also shows that whole grains act as a protective diet against iCVD which a type of cardiovascular disease. Also, the genetic variants about dyslipidemia do not affect the association between carbohydrates and risk of developing iCVD. 

Conclusively, the article is in line with the information I learned from the textbook as well as the findings in earlier research in that some types of dietary carbohydrates such as whole grains have a protective effect on diseases such as CVD and diabetes.

Reference

Sonestedt, E., Hellstrand, S., Schulz, C.-A., Wallström, P., Drake, I., Ericson, U., … Orho-Melander, M. (2015). The Association between Carbohydrate-Rich Foods and Risk of Cardiovascular Disease Is Not Modified by Genetic Susceptibility to Dyslipidemia as Determined by 80 Validated Variants. PLOS ONE, 10(4), e0126104. https://doi.org/10.1371/journal.pone.0126104


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